Chromatography Disc Gp

Eric Grumbach, Marketing Manager, Chemistry Operations for Waters Corporation will speak on «Superficially Porous Particles: A Critical Look».
Pizza and soda at 6 pm, presentation at 6:35. Use the parking garage northwest of McMillen, between Throop Drive and Forest Park Parkway. Go to the Meetings page for more venue, parking, and reservation info. RSVP to bruce_ritts@steris.com by noon on June 8th to ensure that enough food is ordered.
Speaker’s notes: Since the introduction of HPLC nearly 40 years ago, many new stationary phases have been developed to achieve faster, more efficient separations. There are several ways of engineering a column in order to achieve these goals, including: increasing packed bed homogeneity, decreasing intra-particle volume, narrowing particle size distribution, and decreasing the diffusion distance, which can be achieved, in part, by using smaller particles. It can also be achieved by using superficially-porous particles, which have a solid silica core and porous outer shell. Despite the fact that this technology has been around since the 1970s, HPLC columns containing superficially porous (aka, fused-core, core-shell, pellicular) particles have been improved to the point where rapid, highly efficient separations can be achieved for some applications.
In this presentation, we discuss and compare the impact of extra-column band spreading, LC system operating pressure, and separation temperature for sub–2-µm particle and superficially porous particle columns using both conventional HPLC and UPLC® instrumentation.